In vitro antifungal activity of isavuconazole against Madurella mycetomatis.

نویسندگان

  • Wendy Kloezen
  • Jacques F Meis
  • Ilse Curfs-Breuker
  • Ahmed H Fahal
  • Wendy W J van de Sande
چکیده

Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis, with MICs ranging from ≤0.016 to 0.125 μg/ml. Due to its favorable pharmacokinetics, isavuconazole could be a promising antifungal agent in the treatment of mycetoma.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 56 11  شماره 

صفحات  -

تاریخ انتشار 2012